Variation in apolipoprotein (apo)E genotypes predicts variation in plasma cholesterol and apoB; however, the context-dependent associations between high density lipoprotein (HDL) cholesterol, apoA-I, triglycerides, and lipoprotein[a] (Lp[a]) and this polymorphism remain unsettled. We genotyped 5,025 women and 4,035 men sampled to represent a white general population in the age range 20 to 80+ years (mean ages 58 and 57 years for women and men, respectively). The relative frequencies of the varepsilon22, varepsilon32, varepsilon42, varepsilon33, varepsilon43, and varepsilon44 genotypes were 0.005, 0.127, 0.027, 0.564, 0.251, and 0. 027, respectively. Variations in apoE genotype (in the order listed above) predicted stepwise increases in cholesterol and apoB in both genders (all ANOVAs: P < 0.001), and stepwise decreases in HDL cholesterol and apoA-I in women (both ANOVAs: P < 0.001), but not in men. In both genders varepsilon33 individuals had the lowest levels of nonfasting triglycerides, whereas the highest levels were found in individuals with varepsilon22 and varepsilon44 genotypes (both ANOVAs: P < 0.001). Finally, a stepwise increase in Lp[a] was seen in women (ANOVA: P < 0.001), but not in men. In women, the association between variation in nonfasting triglycerides and Lp[a], and variation in apoE genotypes was mainly seen in those with the highest alcohol consumption, similar to the consumption of most men. Variations in apoE genotype predicted 5% and 11% in women, and 2% and 6% in men, of the total variation in plasma cholesterol and apoB, respectively. Variation in levels of plasma lipoproteins is associated with variation in apoE genotypes in the population at large, with the most pronounced association in women, except for nonfasting triglycerides, for which the association is most pronounced in men.Whereas the associations between variation in plasma cholesterol and apoB and the variation in apoE genotypes seem invariant, the associations with variation in plasma HDL cholesterol, apoA-I, nonfasting triglycerides, and Lp[a] seem context dependent.
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【Context-dependent and invariant associations between lipids, lipoproteins, and apolipoproteins and apolipoprotein E genotype.].
【脂质，脂蛋白和载脂蛋白与载脂蛋白E基因型之间的上下文依赖性和不变关联。】
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载脂蛋白 (apo)E基因型的变化可预测血浆胆固醇和apoB的变化; 然而，高密度脂蛋白 (HDL) 胆固醇，apoA-I，甘油三酸酯，和脂蛋白 [a] (Lp[a]) 和这种多态性仍未解决。我们对5,025名女性和4,035名男性进行了基因分型，以代表年龄在20至80岁之间的白人普通人群 (女性和男性的平均年龄为58和57岁，分别)。varepsilon22、varepsilon32、varepsilon42、varepsilon33、varepsilon43和varepsilon44基因型的相对频率分别为0.005、0.127、0.027、0.564、0.251和0.027，apoE基因型的变化 (按上面列出的顺序) 预测两种性别的胆固醇和apoB的逐步增加 (所有anova: P <0.001)，以及女性HDL胆固醇和apoA-I的逐步减少 (两个anova: P <0.001)，但不是在男性中。在两个性别中，varepsilon33个体的非空腹甘油三酯水平最低，而在varepsilon22和varepsilon44基因型的个体中发现最高水平 (两者的方差: P <0.001)。最后，在女性中发现Lp[a] 的逐步增加 (方差分析: P <0.001)，但男性没有。在女性中，非空腹甘油三酯和Lp[a] 的变异与apoE基因型的变异之间的关联主要见于饮酒量最高的人群，与大多数男性的消费相似。apoE基因型的变化分别预测了女性的5% 和11%，以及男性的2% 和6% 血浆胆固醇和apoB的总变化。血浆脂蛋白水平的变化与整个人群中apoE基因型的变化有关，与女性最明显的关联，除了非空腹甘油三酯，男性最明显。血浆胆固醇和apoB的变化与apoE基因型的变化之间的关联似乎是不变的，与血浆HDL胆固醇，apoA-I，非空腹甘油三酯的变化的关联，lp [a] 似乎取决于上下文。
