OBJECTIVE To study the profile of associated autoimmune diseases in a series of patients with systemic lupus erythematosus (SLE) and see if such associations are linked to IgA deficiency. METHODS Two hundred eighty-one patients with SLE were studied for Ig A levels by nephelometry. Levels equal to or under 0.05g/dL were considered as IgA deficiency. Epidemiological and clinical data, including the presence of associated autoimmune diseases, were extracted from the patient's charts. RESULTS Ig A deficiency was found in 6% of the patients. In 30.2% of SLE patients, there was at least one more autoimmune disease; Hashimoto thyroiditis and Sjögren's syndrome were the most common. No association between the occurrence of associated autoimmune disease with IgA deficiency was found. CONCLUSIONS There is a high prevalence of autoimmune diseases associated with SLE. IgA deficiency does not affect the presence of these associations.

译文

目的研究一系列系统性红斑狼疮 (SLE) 患者相关自身免疫性疾病的特征,并探讨这种关联是否与IgA缺乏有关。方法采用散射比浊法检测2 81例SLE患者的Ig A水平。等于或低于0.05g/dL的水平被认为是IgA缺乏症。从患者的图表中提取了流行病学和临床数据,包括相关的自身免疫性疾病的存在。结果6% 患者存在Ig A缺陷。在30.2% SLE患者中,至少还有一种自身免疫性疾病; 桥本甲状腺炎和干燥综合征是最常见的。未发现相关自身免疫性疾病与IgA缺乏症之间的关联。结论系统性红斑狼疮相关的自身免疫性疾病患病率较高。IgA缺乏不影响这些关联的存在。

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