This is the first reported case of human fatality associated with zinc intoxication following a massive ingestion of coins. Four hundred and sixty-one coins were removed form the gastrointestinal tract of a schizophrenic patient during the course of hospitalization. Many of the post-1981 pennies, which consist primarily of zinc, showed severe corrosion due to their prolonged contact with acidic gastric juice. The patient presented with clinical manifestations consistent with the local corrosive as well as systemic effects of zinc intoxication and died 40 days after admission with multi-system organ failure. Tissue samples of the kidneys, pancreas, and liver obtained at autopsy revealed acute tubular necrosis, mild fibrosis, and acute massive necrosis, respectively, and contained high levels of zinc. The overall effects of zinc intoxication on the various organ systems, possible hematological derangement, and the impairment of copper absorption as well as the outcome with treatment are discussed.

译文

这是首次报道的大量摄入硬币后与锌中毒相关的人类死亡病例。在住院期间,从精神分裂症患者的胃肠道中取出了四百六十一枚硬币。许多主要由锌组成的1981后便士由于长时间与酸性胃液接触而显示出严重的腐蚀。患者的临床表现与锌中毒的局部腐蚀性和全身作用一致,入院后40天死于多系统器官衰竭。尸检时获得的肾脏,胰腺和肝脏的组织样本分别显示急性肾小管坏死,轻度纤维化和急性大面积坏死,并且含有高水平的锌。讨论了锌中毒对各种器官系统的总体影响,可能的血液学紊乱以及铜吸收的障碍以及治疗结果。

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