A European multicentric intervention study, led by the colon group of the European Cancer Prevention Organization, is under way. The main aim of the study is to test the efficacy of oral calcium supplementation with 2 g calcium per day and oral dietary supplementation with mucilaginous substances (as 3.8 g of ispaghula husk) on adenoma recurrence. Secondary aims are the study of treatment efficacy on colonic cell proliferation and on stool bile acid and sterol concentration. Serum and plasma samples are also collected. To better interpret the effect of the intervention, a diet history questionnaire and an aspirin and anti-inflammatory drug questionnaire are administered. The aim will be achieved through a randomized placebo-controlled clinical trial using a parallel design in patients aged 35 to 75 at entry with a complete colonoscopy and a clean colon. Overall, 655 subjects have been included. All randomized patients are followed up every six months for 3 years. If one of the evaluated interventions proves efficient, the benefits of a simple, safe and inexpensive prophylaxy for a very common cancer will be clear.

译文

由欧洲癌症预防组织的结肠小组领导的一项欧洲多中心干预研究正在进行中。该研究的主要目的是测试每天口服2g钙的钙补充剂和口服饮食中粘液物质 (如3.8g ispaghula壳) 对腺瘤复发的疗效。次要目的是研究对结肠细胞增殖以及粪便胆汁酸和固醇浓度的治疗效果。还收集血清和血浆样品。为了更好地解释干预的效果,我们使用了饮食史问卷和阿司匹林和抗炎药问卷。该目标将通过一项随机安慰剂对照临床试验来实现,该试验使用平行设计对35至75岁的患者进行完整的结肠镜检查和清洁的结肠。总体而言,已包括655个主题。所有随机患者每6个月随访3年。如果评估的干预措施之一被证明是有效的,那么简单,安全和廉价的预防疗法对非常常见的癌症的好处将是显而易见的。

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