There is an unmet need for high-quality liquid biomarkers that can safely and reproducibly predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The requirement for such markers has intensified because of the high global prevalence of diseases such as non-alcoholic fatty liver disease (NAFLD). In particular, there is a need for diagnostic and prognostic tools, as well as predictive biomarkers that reflect the efficacy of interventions, as described by the BEST criteria (Biomarkers, EndpointS, and other Tools Resource). This review covers the various liver collagens, their functional role in tissue homeostasis and delineates the common nomenclature for biomarkers based on BEST criteria. It addresses the common confounders affecting serological biomarkers, and describes defined collagen epitope biomarkers that originate from the dynamic processes of extracellular matrix (ECM) remodelling during liver injury.

译文

对高质量的液体生物标志物的需求尚未得到满足,这些生物标志物可以安全,可重复地预测纤维化的阶段和慢性肝病 (CLD) 的结果。由于非酒精性脂肪肝病 (NAFLD) 等疾病的全球患病率很高,因此对此类标志物的需求日益增加。特别地,需要诊断和预后工具,以及反映干预效果的预测性生物标志物,如最佳标准 (生物标志物、终点和其他工具资源) 所描述的。这篇综述涵盖了各种肝脏胶原蛋白,它们在组织稳态中的功能作用,并根据最佳标准描述了生物标志物的通用命名法。它解决了影响血清学生物标志物的常见混杂因素,并描述了定义的胶原蛋白表位生物标志物,这些标志物起源于肝损伤期间细胞外基质 (ECM) 重塑的动态过程。

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