The purpose of the present study was to assess posttraumatic stress disorder (PTSD), cognitive function, and quality of life in patients with schizophrenia who had a self-reported history of trauma exposure. Outpatients diagnosed with schizophrenia or schizoaffective disorder were referred to the study. Each patient was assessed with the Positive and Negative Syndrome Scale (PANSS), the Harvard Trauma Questionnaire (HTQ), a cognitive assessment battery, Heinrich's Quality of Life Scale (QLS), and the Behavior and Symptom Identification Scale (BASIS). Eighty-seven subjects who reported experiencing at least one traumatic event were included in the study. Fifteen of 87 (17%) met the DSM-IV criteria for PTSD. The PTSD group had significantly worse overall cognitive performance than the non-PTSD group, especially in the domains of attention, working memory and executive function. In addition, the PTSD group showed significantly worse self-rated quality of life as measured by the BASIS total score. The development of PTSD is associated with poor cognitive function and subjectively, but not objectively, rated low quality of life in patients with schizophrenia. Evaluating PTSD in patients with schizophrenia could have important implications from both clinical and research perspectives.

译文

本研究的目的是评估有自我报告的创伤暴露史的精神分裂症患者的创伤后应激障碍 (PTSD),认知功能和生活质量。诊断为精神分裂症或分裂情感障碍的门诊患者被转介到该研究。用阳性和阴性综合征量表 (PANSS),哈佛创伤问卷 (HTQ),认知评估电池,海因里希生活质量量表 (QLS) 以及行为和症状识别量表 (BASIS) 对每位患者进行评估。该研究包括了87名报告经历至少一次创伤事件的受试者。87个 (17%) 中有15个符合PTSD的dsm-iv标准。PTSD组的整体认知能力明显低于非PTSD组,尤其是在注意力,工作记忆和执行功能方面。此外,根据基础总分,PTSD组的自我评估生活质量明显较差。创伤后应激障碍的发展与认知功能差有关,主观上但不是客观上认为精神分裂症患者的生活质量低。从临床和研究角度评估精神分裂症患者的PTSD可能具有重要意义。

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