Prefrontal cortex influences behavior largely through its connections with other association cortices; however, the nature of the information conveyed by prefrontal output signals and what effect these signals have on computations performed by target structures is largely unknown. To address these questions, we simultaneously recorded the activity of neurons in prefrontal and posterior parietal cortices of monkeys performing a rule-based spatial categorization task. Parietal cortex receives direct prefrontal input, and parietal neurons, like their prefrontal counterparts, exhibit signals that reflect rule-based cognitive processing in this task. By analyzing rapid fluctuations in the cognitive information encoded by activity in the two areas, we obtained evidence that signals reflecting rule-dependent categories were selectively transmitted in a top-down direction from prefrontal to parietal neurons, suggesting that prefrontal output is important for the executive control of distributed cognitive processing.

译文

前额叶皮层主要通过与其他关联皮层的连接来影响行为; 但是,前额叶输出信号传达的信息的性质以及这些信号对目标结构执行的计算有何影响在很大程度上是未知的。为了解决这些问题,我们同时记录了执行基于规则的空间分类任务的猴子的前额叶和后顶叶皮层中神经元的活动。顶叶皮层接收直接的前额叶输入,并且顶叶神经元像前额叶神经元一样,在此任务中表现出反映基于规则的认知处理的信号。通过分析这两个区域活动编码的认知信息的快速波动,我们获得了反映规则依赖类别的信号从前额叶神经元到顶叶神经元有选择地沿自上而下的方向传输的证据,这表明前额叶输出对于分布式认知处理的执行控制很重要。

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