In a prospective magnetic resonance imaging and cognitive study of 38 demented patients and 15 control subjects, 11 of 27 patients with Alzheimer's disease and 8 of 11 patients with vascular dementia had significant periventricular hyperintensities. Memory and language testing in the early investigation of dementia is useful to distinguish patients with or without periventricular hyperintensities on magnetic resonance imaging. Patients without periventricular hyperintensities are worse on memory and conceptualization tests than patients with periventricular hyperintensities, who tend to be worse on comprehension and attention tests. These differences in cognitive pattern are present between patients with different pathogenesis who are otherwise matched for dementia severity. Language and some nonverbal cognitive deficits correlate with the extent of cortical and ventricular atrophy in Alzheimer's disease.

译文

在对38名痴呆患者和15名对照受试者的前瞻性磁共振成像和认知研究中,27例阿尔茨海默氏病患者中的11例和11例血管性痴呆患者中的8例具有明显的脑室周围高信号。在痴呆症的早期研究中进行记忆和语言测试可用于在磁共振成像上区分有无脑室周围高信号的患者。没有脑室周围高强度的患者在记忆和概念化测试上比脑室周围高强度的患者更差,后者在理解和注意力测试上往往更差。这些认知模式的差异存在于具有不同发病机理的患者之间,这些患者在痴呆严重程度上是匹配的。语言和某些非语言认知缺陷与阿尔茨海默氏病的皮质和心室萎缩程度相关。

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