Cannabis is the most widely used illicit substance in the United States with especially high prevalence of use among those with psychiatric disorders. Few studies have examined the relationship between concurrent cannabis use and treatment outcome among patients receiving treatment for comorbid substance abuse and psychiatric disorders. This study investigated the effects of cannabis use on treatment retention and abstinence from cocaine among cocaine dependent patients with Attention Deficit Hyperactivity Disorder (ADHD). Cocaine dependent patients diagnosed with current ADHD (DSM-IV, N = 92) aged 25 to 51 participated in a randomized clinical trial of methylphenidate for treatment of ADHD and cocaine dependence in an outpatient setting. The majority of patients (69%) used cannabis during treatment. Results suggest that moderate/intermittent cannabis users had greater retention rates compared to abstainers and consistent users (p = .02). This study is the first to examine concurrent cannabis use in cocaine dependent patients diagnosed with ADHD.

译文

大麻是美国使用最广泛的非法物质,在精神疾病患者中,大麻的使用率特别高。很少有研究检查同时使用大麻与接受共病药物滥用和精神疾病治疗的患者的治疗结果之间的关系。这项研究调查了使用大麻对可卡因依赖的注意力缺陷多动障碍 (ADHD) 患者的可卡因治疗保留和戒断的影响。25至51岁被诊断为当前ADHD (dsm-iv,N = 92) 的可卡因依赖者参加了哌醋甲酯的随机临床试验,用于在门诊环境中治疗ADHD和可卡因依赖性。大多数患者 (69%) 在治疗期间使用大麻。结果表明,与戒烟者和稳定使用者相比,中度/间歇性大麻使用者的保留率更高 (p = .02)。这项研究是第一个检查诊断为ADHD的可卡因依赖患者同时使用大麻的研究。

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