Dynamic manganese-enhanced magnetic resonance imaging (MEMRI) detects neuronal activity based on the passage of Mn(2+) into active neurons. Because this mechanism is independent of any hemodynamic response, it is potentially ideal for pharmacological studies and was applied to investigate the acute CNS effects of cocaine in the rat. Dose-dependent, region-specific MEMRI signals were seen mostly in cortical and subcortical mesocorticolimbic structures. To verify the spatial accuracy and physiological mechanisms of MEMRI, neuronal activation following electrical forepaw stimulation revealed somatotopic signal enhancement in the primary and secondary somatosensory cortices, which was blocked by diltiazem, a Ca2+ channel antagonist. These data suggest that MEMRI may serve as a tool for investigating the effects of pharmacological agents and opens an application of MRI to study CNS drug effects at a systems level.

译文

动态锰增强磁共振成像 (MEMRI) 基于Mn(2) 进入活动神经元的通道来检测神经元活动。由于该机制与任何血液动力学反应无关,因此它可能是理想的药理学研究,并用于研究可卡因在大鼠中的急性CNS作用。剂量依赖性,区域特异性的MEMRI信号主要出现在皮质和皮质下中皮质边缘结构中。为了验证MEMRI的空间准确性和生理机制,前爪电刺激后的神经元激活揭示了初级和次级体感皮层的体位信号增强,该信号被Ca2通道拮抗剂地尔硫卓阻断。这些数据表明,MEMRI可以用作研究药理作用的工具,并打开了MRI在系统水平上研究CNS药物作用的应用。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录