Diabetes results in several metabolic changes, including alterations in the transport, distribution, excretion, and accumulation of metals. While changes have been examined in several rat models of insulin resistance and diabetes, the metal ion concentrations in the tissues of Zucker lean, Zucker obese (an insulin resistance and early stage diabetes model), and Zucker diabetic fatty (ZDF, a type 2 diabetes model) have not previously been examined in detail. The concentration of Cu, Zn, Fe, Mg, and Ca were examined in the liver, kidney, heart and spleen, and Cr concentration in the liver and kidney of these rats were examined. Zucker obese rats have a reduction in the concentration of Cu, Zn, Fe, Mg in the liver compared to ZDF and/or lean Zucker rats, presumably as a result of the increased fat content of the liver of the obese rats. ZDF rats have increased concentrations of kidney Cu compared to the lean rats, while kidney Ca concentrations are increased in the Zucker obese rats. Spleen Fe concentrations are decreased in Zucker obese rats compared to the lean rats. No effects on metal concentrations in the heart were observed between the lean, obese, and ZDF rats, and no effects on Cr concentrations were identified. Cr(III) complexes have previously been shown to have beneficial effects on the signs of insulin resistance in Zucker obese and ZDF rats. The effects of daily gavage administration of chromium picolinate ([Cr(pic)(3)]) (1 mg Cr/kg body mass), CrCl(3) (1 mg Cr/kg body mass), and Cr3 ([Cr(3)O(propionate)(6)(H(2)O)(3)](+)) (33 μg and 1 mg Cr/kg body mass) on metal concentrations in these tissues were examined. Treatment with CrCl(3) and Cr3, but not [Cr(pic)(3)], at 1 mg Cr/kg resulted in a statistically significant accumulation of Cr in the kidney of lean and obese but not ZDF rats but resulted in lowering the elevated levels of kidney Cu in ZDF rats, suggesting a beneficial effect on this symptom of type 2 diabetes.

译文

糖尿病会导致多种代谢变化,包括运输,分布,排泄和金属积累的改变。虽然已在几种胰岛素抵抗和糖尿病大鼠模型中检查了变化,但Zucker瘦肉,Zucker肥胖 (胰岛素抵抗和早期糖尿病模型) 和Zucker糖尿病脂肪 (ZDF,2型糖尿病) 组织中的金属离子浓度以前尚未详细检查。检查了这些大鼠的肝脏,肾脏,心脏和脾脏中Cu,Zn,Fe,Mg和Ca的浓度,并检查了这些大鼠的肝脏和肾脏中的Cr浓度。与ZDF和/或瘦Zucker大鼠相比,Zucker肥胖大鼠的肝脏中Cu,Zn,Fe,Mg的浓度降低,这可能是由于肥胖大鼠肝脏脂肪含量增加的结果。与瘦大鼠相比,ZDF大鼠的肾脏Cu浓度增加,而Zucker肥胖大鼠的肾脏Ca浓度增加。与瘦大鼠相比,Zucker肥胖大鼠的脾脏Fe浓度降低。在瘦弱,肥胖和ZDF大鼠之间未观察到对心脏中金属浓度的影响,并且未发现对Cr浓度的影响。先前已显示Cr(III) 复合物对Zucker肥胖和ZDF大鼠的胰岛素抵抗迹象具有有益作用。日灌胃给药吡啶甲酸铬 ([Cr(pic)(3)]) (1 mg Cr/kg体重),CrCl(3) (1 mg Cr/kg体重),和Cr3 ([Cr(3)O (丙酸)(6)(H(2)O)(3)]()) (33μg和1 mg Cr/kg体重) 检查了这些组织中的金属浓度。以1 mg Cr/kg的CrCl(3) 和Cr3 (但不包括 [Cr(pic)(3)]) 治疗,导致瘦弱和肥胖但ZDF大鼠肾脏中Cr的统计学显着积累,但ZDF大鼠肾脏Cu水平降低,提示对2型糖尿病的这种症状有有益作用。

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