Chromium has long been known as an enhancer of insulin action. However, the role of chromium in the development of type 2 diabetes mellitus (T2DM) in humans remains controversial. The current study aimed to examine the associations of plasma chromium levels with T2DM and pre-diabetes mellitus (pre-DM). We conducted a case-control study involving 1471 patients with newly diagnosed T2DM, 682 individuals with newly diagnosed pre-DM, and 2290 individuals with normal glucose tolerance in a Chinese population from 2009 to 2014. Plasma chromium was measured by inductively coupled plasma mass spectrometry. Plasma chromium levels were lower in the T2DM and pre-DM groups than in the control group (median: 3.68 μg/L, 3.61 μg/L, 3.97 μg/L, respectively, p < 0.001). After adjustment for potential confounding factors, the odds ratios (95% confidence interval) for T2DM across increasing quartiles of plasma chromium levels were 1 (referent), 0.67 (0.55-0.83), 0.64 (0.51-0.79), and 0.58 (0.46-0.73), respectively (p for trend <0.001). The corresponding odds ratios (95% confidence interval) for pre-DM were 1 (referent), 0.70 (0.54-0.91), 0.67 (0.52-0.88), and 0.58 (0.43-0.78), respectively (p for trend < 0.001). Our results indicated that plasma chromium concentrations were inversely associated with T2DM and pre-DM in Chinese adults.

译文

铬长期以来被认为是胰岛素作用的增强剂。然而,铬在人类2型糖尿病 (T2DM) 发展中的作用仍存在争议。当前的研究旨在检查血浆铬水平与T2DM和糖尿病前期 (pre-DM) 的关系。我们进行了一项病例对照研究,纳入了1471例新诊断的T2DM患者,682例新诊断的糖尿病前期患者和2290例葡萄糖耐量正常的中国人群2009年2014年。通过电感耦合等离子体质谱法测量等离子体铬。T2DM组和pre-DM组的血浆铬水平低于对照组 (中位数: 3.68 μ g/L,3.61 μ g/L,3.97 μ g/L,p <0.001)。在调整了潜在的混杂因素后,血浆铬水平增加的四分位数中T2DM的比值比 (95% 置信区间) 为1 (参照),0.67 (0.55-0.83),0.64 (0.51-0.79) 和0.58 (0.46-0.73),分别 (p表示趋势 <0.001)。前DM的相应优势比 (95% 置信区间) 分别为1 (参照) 、0.70 (0.54-0.91) 、0.67 (0.52-0.88) 和0.58 (0.43-0.78) (p表示趋势 <0.001)。我们的结果表明,中国成年人血浆铬浓度与T2DM和前DM呈负相关。

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