Premature bone resorption and remodeling by osteoclasts can limit the longevity of implant fixation and recovery time. Orally administered bisphosphonates (BPs) have been used to inhibit osteoclast action at the implant/bone interface. Ideally, these should be delivered at the interface with the osteoblast-active hydroxyapatite (HA) for maximum effect. This investigation introduces a novel BP loading technique to achieve improved BP release from a simulated body fluid-grown HA (SBF-HA) with the aim of improving implant fixation. A solution co-precipitation technique incorporates the BP (pamidronate) into a thin SBF-HA coating. Surface analysis, using X-ray photoelectron spectroscopy (XPS), of the resultant coating was employed to confirm the presence of the adsorbed BP on the surface of SBF-HA. XPS analysis was also used to determine the optimal adsorption process. Osteoclast cell culture experiments confirmed the biological effectiveness of BP adsorption and proved that the pamidronate was biologically active, causing both decreased osteoclast numbers and decreased resorption.

译文

破骨细胞过早吸收和重塑会限制植入物固定的寿命和恢复时间。口服双膦酸盐 (BPs) 已用于抑制植入物/骨界面处的破骨细胞作用。理想情况下,这些应在与成骨细胞活性羟基磷灰石 (HA) 的界面处递送,以获得最大效果。这项研究引入了一种新颖的BP加载技术,以改善模拟体液生长的HA (sbf-ha) 中的BP释放,目的是改善植入物的固定。溶液共沉淀技术将BP (帕米膦酸盐) 结合到薄的sbf-ha涂层中。使用x射线光电子能谱 (XPS) 对所得涂层进行表面分析,以确认sbf-ha表面上存在吸附的BP。XPS分析也用于确定最佳吸附过程。破骨细胞培养实验证实了BP吸附的生物学有效性,并证明帕米膦酸盐具有生物活性,导致破骨细胞数量减少和吸收减少。

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