Transcatheter aortic valve replacement (TAVR) causes early acquired thrombocytopenia on postoperative Days 1 and 2 in 30-50% of patients. While usually transient and rarely severe, early acquired thrombocytopenia is strongly associated with 30-day and 1-year post-TAVR outcomes, including mortality. Observation from a prospective registry suggests pretreatment with the P2Y12 receptor inhibitor clopidogrel before TAVR reduces the frequency and magnitude of early acquired thrombocytopenia. If a protective effect of clopidogrel pretreatment on early thrombocytopenia can be confirmed, then further study to determine if this translates into improved TAVR outcomes is warranted.

译文

经导管主动脉瓣置换术 (TAVR) 在30-50% 例患者的术后第1天和第2天引起早期获得性血小板减少症。早期获得性血小板减少症通常是短暂的,很少严重,但与TAVR后30天和1年的结局 (包括死亡率) 密切相关。前瞻性注册表的观察结果表明,在TAVR之前使用P2Y12受体抑制剂氯吡格雷进行预处理可降低早期获得性血小板减少症的频率和幅度。如果可以确认氯吡格雷预处理对早期血小板减少症的保护作用,则需要进一步研究以确定这是否转化为改善的TAVR结局。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录