Clopidogrel is a platelet aggregation inhibitor that increases the risk of bleeding complications when combined with acetylsalicylic acid. We report a rare case of a 79-year-old male treated with clopidogrel and acetylsalicylic acid after coronary angioplasty and stenting to treat unstable angina. Two months after initiation of therapy, the patient presented with symptomatic bilateral pleural effusion. Examination of both effusions confirmed the diagnosis of spontaneous bilateral hemothorax due to combined anti-platelet therapy. Serious functional sequelae were still present 18 months after diagnosis despite bilateral pleural drainage and respiratory physiotherapy.

译文

氯吡格雷是一种血小板聚集抑制剂,与乙酰水杨酸联合使用时会增加出血并发症的风险。我们报告了一例罕见的79岁男性在冠状动脉成形术和支架置入治疗不稳定型心绞痛后接受氯吡格雷和乙酰水杨酸治疗的病例。治疗开始两个月后,患者出现症状性双侧胸腔积液。两次积液的检查证实了由于联合抗血小板治疗而导致的自发性双侧血胸的诊断。尽管双侧胸膜引流和呼吸理疗,但诊断后18个月仍存在严重的功能性后遗症。

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