Selective serotonin reuptake inhibitors (SSRIs) are an efficacious and effective treatment for pediatric obsessive-compulsive disorder (OCD) but have received scrutiny due to a potential side effect constellation called activation syndrome. While recent research introduced a subjective measure of activation syndrome, objective measures have not been tested. This pilot study, using data from a larger randomized-controlled trial, investigated the potential of actigraphy to provide an objective measure of activation symptoms in 44 youths with OCD beginning an SSRI medication regimen. Data were collected over the first four weeks of a multi-site, parallel, double-blind, randomized, placebo controlled psychopharmacological treatment study and statistical modeling was utilized to test how activation syndrome severity predicts daily and nightly activity levels. Results indicated that youths with higher activation symptoms had lower daytime activity levels when treatment averages were analyzed; in contrast youths who experienced onset of activation symptoms one week were more likely to have higher day-time and night-time activity ratings that week. Results support actigraphy as a potential objective measure of activation symptoms. Subsequent studies are needed to confirm these findings and test clinical applications for use by clinicians to monitor activation syndrome during SSRI treatment. National Institutes of Health (5UO1 MH078594-01); NCT00382291.

译文

选择性5-羟色胺再摄取抑制剂 (SSRIs) 是治疗小儿强迫症 (OCD) 的有效方法,但由于潜在的称为激活综合征的副作用而受到审查。尽管最近的研究引入了激活综合征的主观度量,但尚未对客观度量进行测试。这项初步研究使用了一项较大的随机对照试验的数据,研究了在开始SSRI药物治疗方案的44名患有强迫症的年轻人中,激活成像技术提供了客观的激活症状的潜力。在多部位,平行,双盲,随机,安慰剂对照的心理药物治疗研究的前四周收集了数据,并利用统计模型来测试激活综合征的严重程度如何预测每日和每晚的活动水平。结果表明,当分析治疗平均值时,具有较高激活症状的年轻人的白天活动水平较低; 相比之下,一周出现激活症状的年轻人更有可能在该周具有较高的白天和夜间活动评分。结果支持作为激活症状的潜在客观度量。需要随后的研究来证实这些发现并测试临床应用,以供临床医生在SSRI治疗期间监测激活综合征。美国国立卫生研究院 (5UO1 MH078594-01); Nct00382291。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录