The influence of an immunosuppressive cytokine, interleukin-10 (IL-10), on the outcome of hepatitis C virus (HCV) infection has been increasingly reported recently. A number of polymorphisms appear to control the level of IL-10 production. Among them, -592C/A, -819C/T and -1082G/A in the IL-10 gene are three most studied single nucleotide polymorphisms. To provide a more definitive conclusion about their association with the risk of HCV infection, a meta-analysis was performed by combining and summarizing a total of 17 studies. A biological justification for the choice of genetic model was provided. The results indicated no significant association between these IL-10 polymorphisms and the susceptibility to HCV infection [-592C/A: odds ratio (OR) 0.99, 95% confidence interval (CI) 0.78-1.25; -819C/T: OR 0.90, 95% CI 0.69-1.18; -1082G/A: OR 1.34, 95% CI 0.90-2.00]. However, this analysis did not account for the possible risk modifications by other factors, such as ethnicity and virus persistence. Therefore, the effects of ethnicity and virus persistence were investigated using Bayesian meta-regression and subgroup analysis. Finally, an extended case-control association study was conducted in a Chinese population involving 1140 subjects. Both serum level and genotype data of IL-10 -1082G/A were determined. As a result, a low prevalence of G allele was observed. Significantly higher IL-10 production was observed in HCV patients, especially patients with the GG genotype.

译文

最近越来越多的报道了免疫抑制细胞因子interleukin-10 (IL-10) 对丙型肝炎病毒 (HCV) 感染结果的影响。许多多态性似乎控制了IL-10的产生水平。其中,IL-10基因中的-592C/A、-819C/T和-1082G/A是研究最多的三个单核苷酸多态性。为了提供关于他们与HCV感染风险的关系的更明确的结论,通过合并和总结总共17项研究进行了荟萃分析。提供了选择遗传模型的生物学依据。结果表明,这些IL-10多态性与HCV感染易感性之间没有显着关联 [-592C/A: 优势比 (OR) 0.99,95% 置信区间 (CI) 0.78-1.25; -819C/T: 或0.90,95% CI 0.69-1.18; -1082G/A: 或1.34,95% CI 0.90-2.00]。但是,此分析并未考虑其他因素 (例如种族和病毒持久性) 可能导致的风险变化。因此,使用贝叶斯荟萃回归和亚组分析研究了种族和病毒持久性的影响。最后,在涉及1140名受试者的中国人群中进行了扩展的病例对照关联研究。测定IL-10 -1082G/A的血清水平和基因型数据。结果观察到G等位基因的患病率较低。在HCV患者中,尤其是具有GG基因型的患者中,观察到明显更高的IL-10产生。

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