An inverse correlation between geographic distribution of liver cancer incidence and the selenium (Se) contents of whole blood and grains was observed in Qidong county, Jiangsu province, a high liver cancer area of the People's Republic of China. Animal experiments demonstrated that supplementation of Se reduced the incidence of liver cancer in rats exposed to aflatoxin B1. Se was also shown to inhibit the growth of transplanted tumors. A lower incidence of liver preneoplastic alterations and reduction of hepatitis B virus infection in ducks by Se-supplementation was observed, and three pilot studies for a Se-intervention trial on human liver cancer were carried out on the residents of Qidong county. A protective effect on the cellular DNA damage induced by aflatoxin B1 was observed in lympocytes from human with Se-supplements.

译文

在中华人民共和国肝癌高发地区江苏省祁东县,观察到肝癌发病率的地理分布与全血和谷物中的硒 (Se) 含量呈负相关。动物实验表明,补充硒可降低暴露于黄曲霉毒素b1的大鼠的肝癌发生率。还显示Se抑制移植肿瘤的生长。观察到通过补充硒在鸭中肝脏肿瘤前改变的发生率较低,减少了乙型肝炎病毒,并对祁东县居民进行了三项针对人类肝癌的硒干预试验的试点研究。在添加硒补充剂的人淋巴细胞中观察到对黄曲霉毒素B1诱导的细胞DNA损伤的保护作用。

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