Cancer mortality nowadays remains unacceptably high despite immense advances in the understanding of the mechanisms of carcinogenesis, in bringing potent new drugs to the clinic and in treating several rare forms of cancer. Many scientists suggest that overall cancer mortality statistics are unlikely to change in a fundamental way until there has been a re-orientation of emphasis in cancer research that will direct greater resources towards prevention of disease development, rather that treatment of end-stage disease. Cancer chemoprevention represents a rather new rational approach in the management of cancer. Although the results of chemoprevention clinical trials will appear in the near future, the current preclinical and initial clinical published data outline the significant future perspective of cancer chemoprevention.

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尽管在理解致癌机制,将有效的新药引入临床和治疗几种罕见形式的癌症方面取得了巨大进步,但如今的癌症死亡率仍然高得令人无法接受。许多科学家认为,总体癌症死亡率统计数据不太可能以根本的方式改变,除非癌症研究的重点重新定位,这将把更多的资源用于预防疾病发展,而不是治疗终末期疾病。癌症化学预防是癌症治疗中一种相当合理的新方法。尽管化学预防临床试验的结果将在不久的将来出现,但当前临床前和初始临床发表的数据概述了癌症化学预防的重要未来前景。

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