Most living systems, ranging from animal flocks, self-motile microorganisms to the cytoskeleton rely on self-organization processes to perform their own specific function. Despite its importance, the general understanding of how individual active constituents initiate the intriguing pattern formation phenomena on all these different length scales still remains elusive. Here, using a high density actomyosin motility assay system, we show that the observed collective motion arises from a seeding process driven by enhanced acute angle collisions. Once a critical size is reached, the clusters coarsen into high and low density phases each with fixed filament concentrations. The steady state is defined by a balance of collision induced randomization and alignment effects of the filaments by multi-filament collisions within ordered clusters.Self-organization is observed in cytoskeletal systems but emergence of order from disorder is poorly understood. Using a high density actomyosin system, the authors capture the transition from disorder to order, which is driven by enhanced alignment effects caused by increase in multi-filament collisions.

译文

大多数生命系统,从动物鸡群,自我运动的微生物到细胞骨架,都依靠自组织过程来执行自己的特定功能。尽管它很重要,但对单个活性成分如何在所有这些不同长度尺度上引发有趣的图案形成现象的一般理解仍然难以捉摸。在这里,使用高密度的肌动球蛋白运动测定系统,我们表明观察到的集体运动是由增强的锐角碰撞驱动的播种过程引起的。一旦达到临界尺寸,团簇就会粗成高密度和低密度相,每个相具有固定的细丝浓度。稳态由碰撞引起的随机化和有序簇内的多丝碰撞对细丝的排列效应的平衡来定义。在细胞骨架系统中观察到自组织,但对无序有序的出现知之甚少。使用高密度的肌动球蛋白系统,作者捕获了从无序到有序的过渡,这是由多丝碰撞增加引起的增强的对齐效果驱动的。

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