The purpose of this study is to compare the effects of spinal and epidural anesthesia on a rat transverse rectus abdominus myocutaneous flap ischemia-reperfusion injury model.Forty Sprague-Dawley rats were divided into 4 experimental groups: group I (n = 10), sham group; group II (n = 10), control group; group III (n = 10), epidural group; and group IV (n = 10), spinal group. After the elevation of the transverse rectus abdominus myocutaneous flaps, all groups except for the sham group were subjected to normothermic no-flow ischemia for 4 hours, followed by a reperfusion period of 2 hours. At the end of the reperfusion period, biochemical and histopathological evaluations were performed on tissue samples.Although there was no significant difference concerning the malonyldialdehyde, nitric oxide, and paraoxonase levels in the spinal and epidural groups, the total antioxidant state levels were significantly increased, and the total oxidative stress levels were significantly decreased in the epidural group in comparison to the spinal group. The pathological evaluation showed that findings related to inflammation, nuclear change rates and hyalinization were significantly higher in the spinal group compared with the epidural group.Epidural anesthesia can be considered as a more suitable method that enables a decrease in ischemia-reperfusion injuries in the muscle flaps.

译文

本研究的目的是比较脊髓和硬膜外麻醉对大鼠腹直肌横肌肌皮瓣缺血再灌注损伤模型的影响。将40只Sprague-Dawley大鼠分为4个实验组: I组 (n = 10),假手术组; II组 (n = 10),对照组; III组 (n = 10),硬膜外组; IV组 (n = 10),脊髓组。腹直肌肌皮瓣抬高后,除假手术组外,所有组均进行常温无血流缺血4小时,然后再灌注2小时。在再灌注期结束时,对组织样本进行生化和组织病理学评估。尽管脊髓和硬膜外组的丙二醛,一氧化氮和对氧磷酶水平没有显着差异,但总抗氧化状态水平显着增加,与脊髓组相比,硬膜外组的总氧化应激水平显着降低。病理评估表明,与硬膜外组相比,脊柱组与炎症,核改变率和透明化有关的发现明显更高。硬膜外麻醉可以认为是一种更合适的方法,可以减少肌肉皮瓣的缺血再灌注损伤。

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