In recent years, the therapeutic effects of phyto-principles have been appreciated for their promising effects on wound healing. Melia dubia (Malabar neem) possesses anti-cancer, anti-diabetic, anti-tumor, anti-inflammatory, antioxidant, antibacterial, and fungicidal properties. Here, we studied the wound healing efficacy of ethanolic extract of M. dubia leaves on cutaneous wound healing for the first time. The ethanolic extract of M. dubia was applied topically on the wounds of the experimental rats until the wounds heal completely. Wounds of the control rats were treated with PBS. Granulation tissues formed on wound surfaces of the excision wound were harvested on days 4 and 8 and analyzed to determine the total collagen and hexosamine content. Total collagen and hexosamine were significantly (p < .001) higher in M. dubia treated rats compared to control. The rate of wound closure was significantly higher (p < .001) and period of epithelialization was shorter in M. dubia treated rats. Incision wound tissue was used for the tensile strength measurement. Tensile strength was improved in M. dubia treated wound tissues. Results concluded that the topical application of ethanolic extracts of M. dubia improved the rate of wound contraction and tensile strength by increased synthesis of collagen.

译文

近年来,植物原理的治疗作用因其对伤口愈合的有希望的作用而受到赞赏。Melia dubia (Malabar neem) 具有抗癌,抗糖尿病,抗肿瘤,抗炎,抗氧化,抗菌和杀真菌的特性。在这里,我们首次研究了M. dubia叶片的乙醇提取物对皮肤伤口愈合的功效。将M. dubia的乙醇提取物局部涂在实验大鼠的伤口上,直到伤口完全愈合。用PBS治疗对照组大鼠的伤口。在第4天和第8天收获在切除伤口的伤口表面上形成的肉芽组织,并进行分析以确定总胶原蛋白和六糖胺含量。与对照组相比,在dubia M治疗的大鼠中,总胶原蛋白和己糖胺显着升高 (p  < .001)。在dubia M. dubia治疗的大鼠中,伤口闭合率明显较高 (p  < .001),上皮形成时间较短。切口伤口组织用于拉伸强度测量。M. dubia治疗的伤口组织的拉伸强度得到改善。结果得出结论,局部应用M. dubia的乙醇提取物可通过增加胶原蛋白的合成来提高伤口的收缩率和拉伸强度。

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