Cerebrospinal fluid tau (CSF-tau) levels were quantified in 8 patients with frontotemporal dementia (FTD), 6 patients with progressive supranuclear palsy (PSP), 3 patients with corticobasal degeneration (CBD), and 6 patients with dementia with Lewy bodies (DLB). The CSF-tau levels were significantly increased in FTD and DLB, but not in PSP and CBD, compared to that previously reported in normal controls. Notably, the CSF-tau level in DLB was as high as that in Alzheimer's disease (AD). Our study suggests that tau may accumulate in the CSF of patients with certain neurodegenerative diseases other than AD and that measurement of CSF-tau may not distinguish AD from DLB.

译文

对8例额颞叶痴呆 (FTD),6例进行性核上性麻痹 (PSP),3例皮质基底变性 (CBD) 和6例路易体痴呆 (DLB) 患者的脑脊液tau (CSF-tau) 水平进行了定量。与以前在正常对照组中报道的相比,FTD和DLB中的CSF-tau水平显着增加,但PSP和CBD中没有。值得注意的是,DLB中的CSF-tau水平与阿尔茨海默氏病 (AD) 一样高。我们的研究表明,tau可能会在患有AD以外的某些神经退行性疾病的患者的CSF中积累,并且CSF-tau的测量可能无法将AD与DLB区分开。

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