A 58 year old male, chronic smoker, with diabetes mellitus (Type II), residing in Madhya Pradesh presented with dysphagia, hoarseness, odynophagia and significant weight loss. Microlaryngoscopy showed reddish ulcerated area involving valleculae, and pharyngo-epiglottic fold. Histopathological examination showed foamy macrophages containing Histoplasma capsulatum. Patient initially responded to Azoles, relapsed three months after stopping the treatment and presented with oral lesions. Biopsy showed H. capsulatum, histologically as well as on culture. The mycelial phase converted to yeast phase on B.H.I.A. at 37 degrees C confirming the isolate as H. capsulatum. The patient responded well to amphotericin B.

译文

:一位58岁的男性,慢性吸烟者,患有糖尿病(II型),居住在中央邦,患有吞咽困难,声音嘶哑,吞咽困难和体重减轻。微喉镜检查显示溃疡区带红色的溃疡区域,并有咽咽部褶皱。组织病理学检查显示泡沫状巨噬细胞含有荚膜组织胞浆。患者最初对Azoles有反应,在停止治疗后三个月复发,并出现口腔损伤。活检组织学和培养均显示荚膜H.。菌丝体相在B.H.I.A.上转化为酵母相。在37℃下确认该分离物为荚膜H.。该患者对两性霉素B反应良好。

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