B-cell memory is provided by populations of quiescent memory B cells and long-lived plasma cells. Whereas it is clear that both of these cell populations arise from germinal centres, the signals and circumstances that trigger germinal-centre B cells to enter and then persist in memory compartments are poorly defined. Here, I propose that germinal centres produce memory B cells and plasma cells throughout the immune response and that memory B cells arise by the emigration of B cells that are chosen at random from the pool available in the germinal centre. The ability of such emigrants to survive as memory B cells depends on their germinal-centre 'history', with the persistence of high-affinity B-cell variants being favoured.

译文

:B细胞记忆由静态记忆B细胞和长寿浆细胞群体提供。显然,这两个细胞群均起源于生发中心,但触发生发中心B细胞进入并随后在记忆区室中存留的信号和环境的定义不明确。在这里,我建议生发中心在整个免疫反应过程中都会产生记忆B细胞和浆细胞,而记忆B细胞则是通过迁移B细胞而产生的,这些B细胞是从生发中心可用的池中随机选择的。这些移出者作为记忆B细胞存活的能力取决于它们的生发中心“历史”,而高亲和力B细胞变体的持久性受到青睐。

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