Surgery and radiotherapy are the standard treatment options for patients with squamous cell carcinoma of the head and neck (SCCHN). Chemotherapy and chemoradiotherapy are new alternatives for locally advanced disease, particularly induction chemotherapy for patients with unresectable tumors. In recurrent/metastatic disease and after progression to platin-based regimens, no treatments other than best supportive care are currently available. Most SCCHN tumors overexpress the epidermal growth factor receptor (EGFR). This is a tyrosine kinase membrane receptor and has a clear implication in angiogenesis, tumor progression and resistance to different cancer treatments. Cetuximab is a monoclonal antibody that binds to EGFR and alters the tyrosine kinase-mediated signal transduction pathway. The drug is active in colon cancer and is currently being tested in SCCHN patients. For locally advanced disease, cetuximab/radiotherapy combination has demonstrated a benefit in survival when compared with radiotherapy alone as radical treatment. Cetuximab is an active treatment in platin-refractory patients with recurrent/metastatic disease.

译文

:外科手术和放射疗法是头颈部鳞状细胞癌(SCCHN)患者的标准治疗选择。化学疗法和放化疗是局部晚期疾病的新选择,特别是对于无法切除的肿瘤患者的诱导化疗。在复发/转移性疾病中,以及发展为以铂为基础的治疗方案之后,除最佳支持治疗外,目前尚无其他治疗方法。大多数SCCHN肿瘤过表达表皮生长因子受体(EGFR)。这是酪氨酸激酶膜受体,在血管生成,肿瘤进展和对不同癌症治疗的抗性中具有明显的含义。西妥昔单抗是与EGFR结合并改变酪氨酸激酶介导的信号转导途径的单克隆抗体。该药物在结肠癌中有活性,目前正在SCCHN患者中进行测试。对于局部晚期疾病,西妥昔单抗/放疗联合治疗与单纯放疗作为根治性治疗相比,已显示出生存获益。西妥昔单抗是铂类难治性复发/转移性疾病患者的积极治疗方法。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录