A simple, noninvasive method of measuring CBF that uses single photon emission computed tomography (SPECT) of 99mTc-hexamethylpropyleneamine oxime (99mTc-HMPAO) and whole-brain CBF obtained by 133Xe clearance technique was developed. SPECT data were normalized to the count density of HMPAO uptake in the whole brain and then converted to the absolute units of CBF by multiplying average CBF in the whole brain obtained by 133Xe. Mean CBF values in healthy volunteers (n = 12) were 49 +/- 7 and 30 +/- 5 ml 100 g-1 min-1 for gray matter and white matter, respectively, with a global flow value of 45 +/- 5 ml 100 g-1 min-1. The mean flow value was 19 +/- 7 ml 100 g-1 min-1 for the core of the infarct and 31 +/- 5 ml 100 g-1 min-1 for the contralateral region (n = 13). CBF values were reproducible for all brain regions. The method was convenient to use and suitable for the routine measurement of regional CBF in normal and pathologic states.

译文

开发了一种简单,无创的测量CBF的方法,该方法使用99mTc-六甲基丙胺肟(99mTc-HMPAO)的单光子发射计算机断层扫描(SPECT)和通过133Xe清除技术获得的全脑CBF。将SPECT数据标准化为整个大脑中HMPAO摄取的计数密度,然后通过乘以133Xe获得的整个大脑中的平均CBF,将其转换为CBF的绝对单位。健康志愿者(n = 12)的平均CBF值分别为灰质和白质分别为49 /-7和30 /-5 ml 100 g-1 min-1,全局流量值为45 /-5 ml 100 g-1分钟-1。对于梗塞的核心,平均血流值为19/7 ml 100 g-1 min-1,对侧区域的平均血流值为31 /-5 ml 100 g-1 min-1(n = 13)。所有脑区的CBF值均可重现。该方法使用方便,适用于正常和病理状态下区域脑血流的常规测量。

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