Using 133Xe single photon emission tomography, we evaluated the cortical region cerebral blood flow (rCBF) and vascular response to acetazolamide loading before and after vascular reconstructive surgery in 9 hemispheres in 6 patients with adult-onset moyamoya disease. Before the operation, the resting rCBF was not markedly impaired except that several low rCBF regions were present in the frontal and temporal lobes, and after the operation, the number of regions showing normal rCBF was significantly increased. Regional vascular response was more diffusely impaired in the regions with both normal and low rCBF before the operation, the excessively high response observed in the parietal and occipital lobes was well normalized after the operation, while the low response to acetazolamide challenge in the frontal and temporal lobes was not adequately improved.

译文

我们使用133Xe单光子发射断层扫描技术,对6例成年烟雾病患者中9个半球进行血管重建手术前后的皮质区域脑血流量(rCBF)和对乙酰唑酰胺负荷的血管反应进行了评估。术前,静息rCBF并未明显受损,只是额叶和颞叶中存在几个低的rCBF区域,并且术后,显示正常rCBF的区域数量显着增加。术前rCBF正常和较低的区域中区域血管反应均较弥散性受损,在顶叶和枕叶中观察到的过度高反应在术后良好恢复正常,而额叶和颞部对乙酰唑胺攻击的反应低瓣没有得到充分改善。

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