Serum antibodies to cytoskeletal systems were detected, using indirect immunofluorescence in patients with adult T-cell leukemia (ATL), healthy carriers of human T cell lymphotropic virus 1 (HTLV-1), patients with infectious mononucleosis and healthy adults. Healthy carriers of HTLV-1 had IgG antibodies to cytoskeletal systems as evidenced by an increased incidence of IgG antibodies to actin and vimentin. Decreased IgG antibody levels to Epstein-Barr virus nucleic acid (EBNA) were also evident. In patients with ATL, the titers of IgM antibodies to vimentin and cytokeratin showed a positive correlation with decreased serum levels of IgM, despite the fact that serum concentrations of IgM were significantly decreased in patients with ATL. The IgM antibody titer divided by the IgM concentration (the antibody ratio) was nigher than that of healthy carriers and healthy adults, suggesting that the IgM antibody response to cytoskeletal systems was preferentially preserved in these cases. There was also a suggestion of the presence of polyclonal as well as specific antibody responses to cytoskeletal systems in patients with infectious mononucleosis. As a result of these findings we suggest that there is some difference in the mechanisms responsible for the production of autoantibodies to cytoskeletal systems following HTLV-1 infection and Epstein-Barr virus infection.

译文

:在成人T细胞白血病(ATL),健康的人T细胞淋巴病毒1(HTLV-1)携带者,传染性单核细胞增多症患者和健康成年人中,使用间接免疫荧光检测了针对细胞骨架系统的血清抗体。健康的HTLV-1携带者具有针对细胞骨架系统的IgG抗体,这可以通过针对肌动蛋白和波形蛋白的IgG抗体发生率的增加来证明。对爱泼斯坦-巴尔病毒核酸(EBNA)的IgG抗体水平降低也很明显。在ATL患者中,针对波形蛋白和细胞角蛋白的IgM抗体滴度与血清IgM水平降低呈正相关,尽管ATL患者的IgM血清浓度显着降低。 IgM抗体滴度除以IgM浓度(抗体比率)比健康携带者和健康成年人要高,这表明在这些情况下,优先保留了对细胞骨架系统的IgM抗体反应。还提示感染性单核细胞增多症患者存在多克隆以及对细胞骨架系统的特异性抗体反应。这些发现的结果表明,在HTLV-1感染和爱泼斯坦-巴尔病毒感染后,产生针对细胞骨架系统的自身抗体的机制存在一定差异。

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