Oxidation of low density lipoproteins (LDL) favours cholesterol loading in macrophages and formation of "foam cells", typical of the early atheroma lesions. LDL cholesterol oxidation generates oxysterols, extremely cytotoxic molecular species with diverse biological activities. Vegetable polyphenols are dietary components of pharmacological interest for their anti-oxidant properties. Ginkgo biloba L. (Gingkoaceae) leaves and Vaccinium myrtillus L. (Ericaceae) fruits are known for their beneficial effects in the treatment of various diseases involving free radicals and oxidative damage to biological lipids. In this study we investigated the effect of Ginkgo biloba L. and Vaccinium myrtillus L. extracts on the formation of cholesterol oxides during the photo induced oxidation of human LDL. The results demonstrate a concentration dependent inhibition of oxysterol formation in the presence of both extracts. Protection against oxidation was confirmed by the partial restoration of the normal electrophoretic mobility of LDL, which has been influenced by the UV irradiation. These effects extend knowledge of the therapeutic action of Ginkgo biloba L. and Vaccinium myrtillus L. as agents in anti-atherosclerotic regimens.

译文

低密度脂蛋白(LDL)的氧化有助于巨噬细胞中的胆固醇负载和形成“泡沫细胞”,这是早期动脉粥样硬化病变的典型表现。 LDL胆固醇的氧化产生氧固醇,这是具有多种生物活性的极具细胞毒性的分子物种。植物多酚因其抗氧化性能而成为具有药理学意义的饮食成分。银杏叶(Gingkoaceae)叶和牛痘越橘(Ericaceae)水果因其在治疗多种疾病中的有益作用而广为人知,这些疾病涉及自由基和对生物脂质的氧化损伤。在这项研究中,我们研究了银杏叶提取物和牛痘越桔提取物在光诱导人LDL氧化过程中对胆固醇氧化物形成的影响。结果表明在两种提取物存在下,浓度依赖性抑制氧固醇的形成。 LDL的正常电泳迁移率已部分恢复,这证实了抗氧化的作用,该迁移率已受到紫外线辐射的影响。这些作用扩展了银杏叶和越桔越桔作为抗动脉粥样硬化治疗剂的治疗作用的知识。

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