The double-J stents used today for palliative artificial urinary diversion very often show extreme formation of encrustations, even a short time after implantation. Despite increased scientific material development, the complication rate has not really been strongly influenced. Grant-aided by the German Federal Ministry of Education and Research, we chose a new interdisciplinary and translational approach by coating standard stent materials with plasma-deposited amorphous diamond-like carbon. These stents show clearly reduced rates of encrustation in vitro. Ongoing clinical trials demonstrate a further enhancement of this effect in vivo. The underlying mechanisms are being investigated by extending the established in vitro model, thereby pushing research in this field to a new level.

译文

:如今,用于姑息性人工尿道改道的双J支架在植入后很短时间内经常表现出结壳的极端形成。尽管科学材料的发展有所增加,但并发症的发生率并没有受到很大的影响。在德国联邦教育和研究部的资助下,我们选择了一种新的跨学科和平移方法,即在等离子沉积的非晶态类金刚石碳上涂覆标准支架材料。这些支架在体外明显显示出降低的结壳率。正在进行的临床试验表明,这种作用在体内的进一步增强。正在通过扩展已建立的体外模型来研究其潜在机制,从而将这一领域的研究推向新的高度。

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