We report a simple and facile method to prepare a novel pH sensitive polyampholyte nanogel by copolymerizing vinylimidazole (VIM) with acrylic acid (AA) using functionalized single-walled carbon nanotubes (f-SWCNTs) (as reinforcing material) and cyanuric chloride via an intermolecular quaternization reaction. The polyampholyte nanogels have been characterized by various microscopic and spectroscopic methods. These studies reveal that incorporation of nanotubes in cross-linked copolymer of poly(vinylimidazole-co-acrylic acid) (PVI-co-AA) form polyampholyte nanogel with enhanced physical properties. The thermal experiments show that the introduction of f-SWCNTs into PVI-co-AA has significant impact on the thermal stability of nanogels. The rheological study showed that the nanogel is more viscoelastic than native gel. MTT assay indicates that the prepared polyampholyte gels possess biocompatibility and cell viability. The nanogel is also useful material to load water-soluble drug such as promethazine hydrochloride. The releasing profile of the drug from the nanogel clearly shows the pH-sensitive property of the material.

译文

:我们报告了一种简单易行的方法,该方法通过使用功能化的单壁碳纳米管(f-SWCNTs)(作为增强材料)和氰尿酰氯通过共聚乙烯基咪唑(VIM)与丙烯酸(AA)来制备新型pH敏感的聚两性电解质纳米凝胶。分子间季铵化反应。聚两性电解质纳米凝胶已经通过各种显微镜和光谱方法表征。这些研究表明,将纳米管并入聚(乙烯基咪唑-丙烯酸)(PVI-co-AA)的交联共聚物中可形成具有增强物理性能的聚两性电解质纳米凝胶。热实验表明,将f-SWCNTs引入PVI-co-AA对纳米凝胶的热稳定性有重大影响。流变学研究表明,纳米凝胶比天然凝胶更具粘弹性。 MTT分析表明,所制备的两性凝胶具有生物相容性和细胞活力。纳米凝胶也是用于加载水溶性药物如盐酸异丙嗪的有用材料。药物从纳米凝胶的释放曲线清楚地表明了该材料的pH敏感特性。

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