Angiotensin converting enzyme inhibitors reduce blood pressure without reflex tachycardia, possibly as a result of enhanced hypothesis that this results from the removal of the parasympathetic activity. We examined the vagolytic action of angiotensin II or alternatively by acetylcholinesterase inhibition. Both captopril and [Sar1ala8] angiotensin II, (saralasin), caused modest falls in blood pressure, without increasing heart rate in normotensive subjects. Captopril and saralasin significantly attenuated the vagally mediated heart rate slowing after facial immersion in water. There was a close correlation between the effects produced by captopril and saralasin on the diving reflex. Infusion of subpressor doses of angiotensin II, reversed the hypotensive effect of captopril and returned the bradycardia after facial immersion to placebo level. In vitro neither captopril nor enalapril or lisinopril affected bovine erythrocyte acetylcholinesterase activity. The parasympathetic effect of angiotensin converting enzyme inhibitors appear to reflect a direct consequence of the removal of angiotensin II.

译文

:血管紧张素转换酶抑制剂可降低血压而无反射性心动过速,这可能是由于假说交感神经活动被消除导致假说增强的结果。我们检查了血管紧张素II或通过乙酰胆碱酯酶抑制的迷走神经作用。卡托普利和[Sar1ala8]血管紧张素II(萨拉生素)均引起血压适度下降,而血压正常者的心率却没有增加。卡托普利和撒拉辛在面部浸入水中后可显着减弱阴道介导的心率减慢。卡托普利和萨拉信素对潜水反射产生的影响之间存在密切的相关性。输注低于剂量的血管紧张素II,可逆转卡托普利的降压作用,并使面部浸入后的心动过缓恢复至安慰剂水平。在体外,卡托普利,依那普利或赖诺普利均不影响牛红细胞乙酰胆碱酯酶活性。血管紧张素转化酶抑制剂的副交感作用似乎反映了血管紧张素II去除的直接后果。

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