It has been known since 1851 that atmospheric oxygen is taken up by the human epidermis. The contribution to total respiration is negligible. Until now the significance for the local oxygen supply of the skin has remained unknown. With a newly developed sensor, the oxygen fluxoptode, it has become possible to make local measurements of the transcutaneous oxygen flux (tcJ(O2)). In this study the sensor was calibrated so that absolute values of tcJ(O2) could be reported. At rest, tcJ(O2) was determined on normal, humidified skin on the volar forearm of 20 volunteers of different age groups. In order to evaluate the contribution of the blood flow to the oxygen supply of the skin, tcJ(O2) was recorded at the end of a 5 min suprasystolic occlusion of the forearm. At normal skin surface partial oxygen pressure (163 +/- 9 Torr), tcJ(O2) was 0.53 +/- 0.27 ml O2 min(-1) x m(-2). A 5 min interruption of blood flow resulted in an increase of 9.5 +/- 6.3 % in tcJ(O2). The value of tcJ(O2) was unaffected by the age of the subject. Published data on the oxygen diffusion properties of skin and simulations of intracutaneous profiles of oxygen partial pressure indicated that under these conditions, the upper skin layers to a depth of of 0.25-0.40 mm are almost exclusively supplied by external oxygen, whereas the oxygen transport of the blood has a minor influence. As a consequence, a malfunction in capillary oxygen transport cannot be the initiator of the development of superficial skin defects such as those observed in chronic venous incompetence and peripheral arterial occlusive disease.

译文

1851年已经知道,大气中的氧气被人的表皮吸收。对总呼吸的贡献可以忽略不计。到目前为止,皮肤局部氧气供应的重要性仍然未知。借助新开发的传感器氧气通量,可以对经皮氧气通量 (tcJ(O2)) 进行局部测量。在这项研究中,对传感器进行了校准,以便可以报告tcJ(O2) 的绝对值。休息时,在20个不同年龄组的志愿者的前臂掌侧正常湿润皮肤上测定tcJ(O2)。为了评估血流对皮肤氧气供应的贡献,在前臂5分钟的上动脉闭塞结束时记录了tcJ(O2)。在正常皮肤表面氧分压 (163 +/- 9 Torr) 下,tcJ(O2) 为0.53 +/-0.27毫升O2 min(-1) × m(-2)。血流中断5分钟导致tcJ(O2) 的9.5 +/- 6.3% 增加。tcJ(O2) 的值不受受试者年龄的影响。关于皮肤的氧气扩散特性的公开数据和氧分压的皮内分布的模拟表明,在这些条件下,上层皮肤层至0.25-0.40毫米的深度几乎完全由外部氧气供应,而氧气的输送血液的影响很小。结果,毛细血管氧运输的故障不能成为浅表皮肤缺损发展的始作俑者,例如在慢性静脉功能不全和外周动脉闭塞性疾病中观察到的那些。

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