Congenital anomalies are a leading cause of infant mortality and are important contributors to subsequent morbidity. Studies suggest associations between environmental contaminants and some anomalies, although evidence is limited. We aimed to investigate whether ambient air pollutant and traffic exposures in early gestation contribute to the risk of selected congenital anomalies in the San Joaquin Valley of California, 1997-2006. Seven exposures and 5 outcomes were included for a total of 35 investigated associations. We observed increased odds of neural tube defects when comparing the highest with the lowest quartile of exposure for several pollutants after adjusting for maternal race/ethnicity, education, and multivitamin use. The adjusted odds ratio for neural tube defects among those with the highest carbon monoxide exposure was 1.9 (95% confidence interval: 1.1, 3.2) compared with those with the lowest exposure, and there was a monotonic exposure-response across quartiles. The highest quartile of nitrogen oxide exposure was associated with neural tube defects (adjusted odds ratio = 1.8, 95% confidence interval: 1.1, 2.8). The adjusted odds ratio for the highest quartile of nitrogen dioxide exposure was 1.7 (95% confidence interval: 1.1, 2.7). Ozone was associated with decreased odds of neural tube defects. Our results extend the limited body of evidence regarding air pollution exposure and adverse birth outcomes.

译文

:先天性异常是婴儿死亡的主要原因,并且是随后发病的重要原因。研究表明,尽管证据有限,但环境污染物与某些异常之间存在关联。我们的目的是调查1997-2006年加利福尼亚州圣华金河谷的环境空气污染物和妊娠早期的交通暴露是否会导致某些先天性异常的风险。总共35个被调查的协会包括7次暴露和5个结果。在调整了母体种族/民族,教育程度和多种维生素使用量后,比较几种污染物的最高和最低四分位数的暴露量,我们观察到了神经管缺陷的几率增加。一氧化碳暴露最高者的神经管缺陷校正比值比为最低暴露者,其调整后的优势比为1.9(95%置信区间:1.1、3.2),四分位数之间存在单调的暴露响应。氮氧化物暴露的最高四分位数与神经管缺陷有关(调整的优势比= 1.8、95%置信区间:1.1、2.8)。二氧化氮暴露的最高四分位数的调整后优势比为1.7(95%置信区间:1.1、2.7)。臭氧与神经管缺损几率降低有关。我们的结果扩展了有关空气污染暴露和不良出生结局的有限证据。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录