By treating C3 with purified C1, C4 and C2 in the fluid phase, haemolytically inactive C3 was prepared. This was shown to bind to human erythrocytes by use of radio-labelled (Fab')2 antibody to guinea-pig C3. The activated C3 preparation inhibited immune adherence between EAC43 and human erythrocytes. These findings indicate that the activated C3 attaches to the immune adherence receptor on human erythrocytes. In addition the fluid-phase activated C3 adhered to thymus cells and sheep erythrocytes, whereas EAC43 did not. Thus the immune adherence receptor may be present on so called immune adherence-negative cells, but in insufficient concentration to form rosettes with EAC43.

译文

:通过在液相中用纯化的C1,C4和C2处理C3,制备了具有溶血活性的C3。通过使用针对豚鼠C3的放射性标记的(Fab')2抗体,该抗体可与人红细胞结合。活化的C3制剂可抑制EAC43与人类红细胞之间的免疫粘附。这些发现表明,活化的C3附着在人红细胞上的免疫粘附受体上。此外,液相活化的C3附着在胸腺细胞和绵羊红细胞上,而EAC43则没有。因此,免疫粘附受体可能存在于所谓的免疫粘附阴性细胞上,但浓度不足以与EAC43形成玫瑰花结。

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