With an ever-increasing clinical interest in vitamin D insufficiency, numerous automated immunoassays, protein binding assays, and in-house LC-MS/MS methods are being developed for the quantification of 25-hydroxyvitamin D(3) (25(OH)D(3)). Recently, LC-MS/MS methods have identified an epimeric form of 25(OH)D(3) that has been shown to contribute significantly to 25(OH)D(3) concentration, particularly in infant populations. This review describes the metabolic pathway and physiological functions of 3-epi-vitamin D, compares the capability of various 25(OH)D(3) methods to detect the epimer, and highlights recent publications quantifying 3-epi-25(OH)D(3) in infant, pediatric, and adult populations. In total, this review summarizes the information necessary for clinicians and laboratorians to decide whether or not to report/consider the C3-epimer in the analysis and clinical assessment of vitamin D status.

译文

:随着对维生素D功能不足的临床兴趣的日益增长,正在开发大量自动免疫测定,蛋白质结合测定和内部LC-MS / MS方法来定量25-羟基维生素D(3)(25(OH) D(3))。最近,LC-MS / MS方法已经鉴定出25(OH)D(3)的一种异构体形式,已证明对25(OH)D(3)的浓度有显着贡献,尤其是在婴儿人群中。这篇综述描述了3-表位维生素D的代谢途径和生理功能,比较了各种25(OH)D(3)方法检测差向异构体的能力,并着重介绍了量化3-epi-25(OH)D的最新出版物。 (3)在婴儿,儿科和成人人群中。总的来说,该综述总结了临床医生和实验室医师决定在维生素D状况的分析和临床评估中是否报告/考虑C3受体的必要信息。

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