Evidence of the existence of a special decodifier on the effector cells, with which inductor substances must interact in order to trigger their characteristic responses, has been found since the beginning of the century. These cytoplasmic sites are able to recognize, accept and receive the message transmitted by the inductor substance, giving rise to a specific cell response. Thus, the inductor-receptor binding complex interaction at the cellular level may alter permeability to ions as happens with neuro-transmitters, or can trigger pinocytosis in the case of apolipoproteins. Cellular receptors have been involved in the mechanism of action of several drugs and its dysfunction explains the physiopathology of a number of diseases. This may involve diminished clathrin protein synthesis triggering a defect in affinity, such as seen in malnutrition. It is also applicable in genetic disturbances, which are capable of precluding receptor development as in cases of familiar hypercholesterolemia.

译文

自本世纪初以来,已经发现了效应细胞上存在特殊解毒剂的证据,诱导物质必须与该解毒剂相互作用以触发其特征反应。这些细胞质位点能够识别,接受和接收由诱导剂物质传输的消息,从而引起特定的细胞反应。因此,在细胞水平上的诱导剂-受体结合复合物相互作用可能会像神经递质一样改变对离子的渗透性,或者在载脂蛋白的情况下会触发胞吞作用。细胞受体已参与多种药物的作用机制,其功能障碍解释了许多疾病的病理生理。这可能涉及网格蛋白合成减少,从而引发亲和力缺陷,例如营养不良。它也适用于遗传紊乱,就像熟悉的高胆固醇血症一样,能够阻止受体的发育。

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