OBJECTIVE:The aim of the present study was to evaluate anti-inflammatory activity of methanolic extract of Terminalia coriacea. MATERIALS AND METHODS:A methanolic extract of T. coriacea leaves was studied in albino Wistar rats with carrageenan-induced paw edema, an acute model, and cotton pellet-induced granuloma, a chronic model, at 3 oral test doses (125, 250, and 500 mg/kg). Aspirin 100 mg/kg was used as a positive control. Paw volume and wet and dry weights of cotton pellets were determined. The data were analyzed by one-way ANOVA followed by Dunnett's multiple comparison test. RESULTS:The test extract at doses of 125 and 250 mg/kg decreased paw volume and wet and dry weights of cotton pellets. The highest test dose (500 mg/kg) displayed a response comparable to that of the standard drug (p < 0.01) on paw volume. The extract produced similar (p < 0.05) decrease in wet weight of the cotton pellet at 125 and 250 mg/kg, whereas the effect of 500 mg/kg of the extract was comparable to that of aspirin 100 mg/kg (p < 0.01). The extract of T. coriacea at 500 mg/kg induced the most significant (p < 0.01) effect on wet weight of granulomatous tissue. CONCLUSION:The methanolic extract of T. coriacea leaves successfully decreased paw edema as well as dry and wet weights of granulomatous tissue in both acute and chronic inflammatory models thus confirming the anti- edematogenic, antitransudative, and antiproliferative properties of T. coriacea.

译文

目的:本研究旨在评价榄仁(Terminalia coriacea)甲醇提取物的抗炎活性。
材料与方法:在3种口服试验剂量下,在患有角叉菜胶诱发的爪水肿(急性模型)和棉丸诱发的肉芽肿(慢性模型)的白化病Wistar大鼠中研究了紫T叶的甲醇提取物(125、250,和500 mg / kg)。阿司匹林100 mg / kg用作阳性对照。测定棉花粒料的爪体积和湿重和干重。数据通过单因素方差分析(ANOVA),然后进行邓尼特的多重比较检验进行分析。
结果:125和250 mg / kg剂量的测试提取物减少了棉花粒的爪体积和干湿重。最高测试剂量(500 mg / kg)在爪子体积上显示出与标准药物相当的响应(p <0.01)。提取物在125和250 mg / kg时棉团的湿重降低程度相似(p <0.05),而500 mg / kg提取物的效果与阿司匹林100 mg / kg相当(p <0.01) )。 500 mg / kg的T草提取物对肉芽肿组织的湿重产生最显着的影响(p <0.01)。
结论:在急性和慢性炎症模型中,桔梗叶的甲醇提取物均能成功减轻爪水肿以及肉芽肿组织的干重和湿重,从而证实了桔梗的抗水肿,抗渗出和抗增殖特性。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录