3-nitro-9-[2-(dialkylamino)ethyl)]aminoacridines (alkyl = methyl or ethyl) have been used as ligands towards platinum(If). The end product is a complex in which the acridine acts as a tridentate ligand contributing the two exocyclic nitrogen atoms and one of the two peri carbons. The metallation takes place predominantly at the peri position of the unsubstituted ring. The coordinated acridine is in the imino tautomeric form although, in the free state, it occurs exclusively in the amino form (both in the solid state and in solution). The imino tautomer is considered to be the biologically active form. In the platinated species the N(10)H of the acridine can be involved in strong hydrogen bonding with a chloride ion leading to formation of an association complex, the formation constant has been found to be 1.4+/-10(3) M(-1). The N(10)H...CI interaction can influence the tautomeric equilibrium of the acridine dye also in the uncoordinated species, however, the shift in favor of the imino tautomer is not complete.

译文

3-硝基-9-[2-(二烷基氨基) 乙基)] 氨基ac啶 (烷基 = 甲基或乙基) 已被用作铂 (If) 的配体。最终产物是一种复合物,其中a啶充当三齿配体,贡献两个环外氮原子和两个环碳之一。金属化主要发生在未取代环的周围位置。配位的a啶呈亚氨基互变异构形式,尽管在自由状态下,它仅以氨基形式存在 (固态和溶液中)。亚氨基互变异构体被认为是生物活性形式。在铂化物质中,吖啶的N(10)H可能参与与氯离子的强氢键,导致缔合配合物的形成,已发现形成常数为1.4 +/-10(3) M(-1)。N(10)H...CI相互作用也会在不协调的物种中影响吖啶染料的互变异构平衡,但是,有利于亚氨基互变异构体的转变尚未完成。

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