OBJECTIVES:To evaluate the principal features of focal cemento-osseous dysplasia (FocCOD) by systematic review (SR) and to compare their frequencies between four global groups. METHODS:Alternative names for FocCOD were used as search terms. The databases searched were the PubMed interface of Medline and LILACS (Literature Index for Latin-America and the Caribbean; Biblioteca Regional de Medicina (BIREME)). Only those reports of FocCODs which occurred in a series in the reporting authors' caseload were considered. All cases used radiographs and were confirmed fibro-osseous lesions histopathologically. RESULTS:Of the 20 series considered, 10 were included in the SR. Five SR-included series were of East Asian communities. 64% of all SR-included cases were found incidentally. FocCOD predominantly affects females and the mandible. The three predominant radiological presentations varied significantly between reports. CONCLUSIONS:The two at-risk global communities appear to be East Asians and those of black African origin. Although there appears to be little difference between East Asians and non-East Asians, the significant differences between them with regards to the predominant radiological presentation could suggest that either all communities vary in their presentation or that most, if not all, did not reflect the true frequency within their communities. Long-term follow-up of large series that would have revealed the long-term outcomes of FocCODs was lacking. This is necessary because of both FocCOD's predilection of edentulous areas, increasingly required for osseointegrated implants, and its wide differential diagnosis, which includes some lesions normally treated by surgery.

译文

目的:通过系统评价(SR)评估局灶性骨水泥性骨发育不良(FocCOD)的主要特征,并比较其在四个全球性人群之间的发生频率。
方法:使用FocCOD的替代名称作为搜索词。搜索的数据库是Medline和LILACS的PubMed界面(拉丁美洲和加勒比海文学索引;医学图书馆区域(BIREME))。仅考虑在报告作者案例中出现的一系列FocCOD报告。所有病例均用X线片检查,并在组织病理学上证实为纤维骨病变。
结果:在考虑的20个系列中,有10个包含在SR中。五个包含SR的系列是东亚社区。在所有包含SR的案例中,有64%是偶然发现的。 FocCOD主要影响女性和下颌骨。报告之间的三个主要放射学表现差异很大。
结论:两个高风险的全球社区似乎是东亚人和非洲黑人血统。尽管东亚人与非东亚人之间似乎没有什么区别,但是在主要的放射学表现方面,他们之间的显着差异可能表明,所有社区的表现都各不相同,或者大多数(如果不是全部)都没有反映出他们社区内的真实频率。尚缺乏对可能会揭示FocCOD长期结果的大系列药物的长期随访。这是必要的,因为FocCOD偏爱无牙区域(对骨整合植入物的要求越来越高)及其广泛的鉴别诊断(包括一些通常通过手术治疗的病变)。

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