Patients with chronic bronchitis were randomly allocated to 4 weeks treatment with terbutaline 0.5 mg inhaled through a cone spacer with an expiratory resistance creating a positive expiratory pressure (+PEP group) or without (-PEP group). The patients recorded their symptoms in a diary and peak expiratory flow (PEFR) was measured before and after each inhalation. PEFR increased significantly after inhaled terbutaline both with and without PEP. The mean increase in PEFR after terbutaline inhalations was significantly greater (p less than 0.0001) in the +PEP group (24 L/min) compared to the -PEP group (17 L/min). The +PEP group had less sputum and less difficulty with coughing up sputum compared to the -PEP group. This study showed a small but significant enhancement of the bronchodilation and a beneficial effect on symptoms when inhalation of beta-2-agonist was combined with PEP in patients with chronic bronchitis.

译文

:患有慢性支气管炎的患者被随机分配到4周的治疗中,通过圆锥形间隔器吸入0.5 mg的特布他林,产生呼气阻力时产生正压(PEP组)或不呼气(-PEP组)。患者在日记中记录了他们的症状,并在每次吸入之前和之后测量了最大呼气流量(PEFR)。在有和没有PEP的情况下吸入特布他林后,PEFR均显着增加。与-PEP组(17 L / min)相比,PEP组(24 L / min)吸入特布他林后PEFR的平均增加显着更大(p小于0.0001)。与-PEP组相比,PEP组的痰少,咳嗽困难少。这项研究表明,在慢性支气管炎患者中,吸入β-2-激动剂与PEP联合使用时,支气管扩张作用小而显着增强,并且对症状有有益效果。

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