152 patients with thromboangiitis obliterans (Buerger's disease) and pain from critical leg ischaemia were randomly allocated to receive iloprost, a chemically stable prostacyclin analogue, or low-dose aspirin, for 28 days in a double-blind trial. On review, 19 patients did not fulfil the stringent entry criteria. Of the other 133 patients, 98 also had leg ulcers. After 21-28 days, 58 (85%) of 68 iloprost-treated patients showed ulcer healing or relief of ischaemic pain, compared with 11 (17%) of 65 in the aspirin-treated group. 43 (63%) on iloprost treatment had complete relief of pain, compared with 18 (28%) on aspirin. Ulcers healed completely in 18 of 52 (35%) who received iloprost compared with 6 of 46 (13%) who received aspirin. 6 months after the start of treatment, the response rate was 45 of 51 (88%) patients treated with iloprost compared with 12 of 44 (21%) patients treated with aspirin.

译文

在双盲试验中,将152名患有闭塞性血栓性血管炎(Buerger病)和因严重下肢缺血的疼痛的患者随机分配接受伊洛前列素(伊洛前列素),伊洛前列素是一种化学稳定的前列环素类似物或小剂量阿司匹林。经复查,有19名患者不符合严格的入院标准。在其他133名患者中,有98名还患有腿部溃疡。 21-28天后,接受伊洛前列素治疗的68位患者中有58位(85%)溃疡愈合或减轻了缺血性疼痛,而阿司匹林治疗组的65位中有11位(17%)。伊洛前列素治疗组中有43(63%)名患者完全缓解了疼痛,而阿司匹林治疗组中只有18(28%)名。接受伊洛前列素的52名患者中有18名(35%)的溃疡完全治愈,而接受阿司匹林的46名患者中有6名(13%)的溃疡得到了完全治愈。在开始治疗后的6个月,伊洛前列素治疗的51例患者中有45例(88%)有效率,而阿司匹林治疗的44例患者中有12例(21%)有效率。

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