BACKGROUND & AIMS:
:We investigated the somatic maturation of neonate rats treated during the suckling period with citalopram, a selective serotonin reuptake inhibitor. Groups with 6 male neonates were randomly assigned to different treatments 24 h after birth. Each litter was suckled by one of the dams until the 21st postnatal day. Body weight, head axis and tail length were measured daily from the 1st to the 21st postnatal day. Time of ear unfolding, auditory conduit opening, incisor eruption, and eye opening was determined. Pups received 5 mg (Cit5), 10 mg (Cit10) or 20 mg/kg (Cit20) citalopram sc, or saline (0.9% NaCl, w/v, sc). Compared to saline, body weight was lower (24.04%, P < 0.01) for Cit10 from the 10th to the 21st day and for Cit20 from the 6th to the 21st day (38.19%, P < 0.01). Tail length was reduced in the Cit20 group (15.48%, P < 0.001) from the 8th to the 21st day. A reduction in mediolateral head axis (10.53%, P < 0.05) was observed from the 11th to the 21st day in Cit10 and from the 6th to the 21st day in Cit20 (13.16%, P < 0.001). A reduction in anteroposterior head axis was also observed in the Cit20 group (5.28%, P < 0.05) from the 13th to the 21st day. Conversely, this axis showed accelerated growth from the 12th to the 21st day in the Cit5 group (13.05%, P < 0.05). Auditory conduit opening was delayed in the Cit5 and Cit20 groups and incisor eruption was delayed in all citalopram groups. These findings show that citalopram injected during suckling to rats induces body alterations and suggest that the activity of the serotoninergic system participates in growth mechanisms.
背景与目标:
: 我们研究了在哺乳期间用选择性5-羟色胺再摄取抑制剂西酞普兰治疗的新生大鼠的体细胞成熟。出生后24小时,将6名男性新生儿随机分配到不同的治疗方法中。直到出生后的第21天,每窝都被其中一个水坝所吸。从出生后的第1天到第21天每天测量体重,头轴和尾巴长度。确定了耳朵展开,听觉导管打开,门牙萌出和眼睛张开的时间。幼崽接受5 mg (Cit5) 、10 mg (Cit10) 或20 mg/kg (Cit20) 西酞普兰sc或生理盐水 (0.9% NaCl,w/v,sc)。与生理盐水相比,Cit10从第10天到第21天的体重较低 (24.04%,P <0.01),Cit20从第6天到第21天的体重较低 (38.19%,P <0.01)。从第8天到第21天,Cit20组的尾长减少 (15.48%,P <0.001)。在Cit10的第11天至第21天以及在Cit20的第6天至第21天观察到中外侧头轴的降低 (10.53%,P <0.05) (13.16%,P <0.001)。从第13天到第21天,Cit20组也观察到前后头轴降低 (5.28%,P <0.05)。相反,该轴显示Cit5组从第12天到第21天的加速增长 (13.05%,P <0.05)。Cit5和Cit20组的听觉导管开放延迟,所有西酞普兰组的门牙喷发延迟。这些发现表明,在给大鼠哺乳期间注射西酞普兰会引起身体改变,并表明5-羟色胺能系统的活性参与了生长机制。