Women of African descent have a lower incidence of breast cancer than their white counterparts; however, the overall age-adjusted breast cancer mortality rates are higher. They also present at a younger age, and have more advanced disease that exhibits poor prognostic features including significantly larger tumors of higher grade, higher rates of estrogen receptor and progesterone receptor negativity and a higher rate of p53 mutations and HRAS1 proto-oncogene expression, all of which confer a poor prognosis. While there are many possible contributory factors to the discrepancies in outcome in women of African descent, there is no satisfactory explanation as to why women of African origin tend to present at a younger age with hormone receptor-negative tumors and more adverse prognostic features.

译文

:非洲裔女性的乳腺癌发病率低于白人女性;但是,按年龄调整的总体乳腺癌死亡率更高。它们也以较年轻的年龄出现,并具有较晚期的疾病,表现出不良的预后特征,包括更高级别的明显更大的肿瘤,更高的雌激素受体和孕激素受体阴性率以及更高的p53突变和HRAS1原癌基因表达率,所有其中预后不良。尽管有许多可能的因素导致非洲人后裔的结果差异,但对于为什么非洲人后裔倾向于在年轻时出现激素受体阴性肿瘤和更不利的预后特征尚无令人满意的解释。

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