BACKGROUND:This study aimed at analyzing different treatments of breast cancer (BC) prevalent in the region, their effect on patients' survival, and discusses the most suitable method within available resources. METHODS:The study was set up at a tertiary care hospital in north India. We retrospectively reviewed data of 473 female BC patients who attended the departments of Surgical Oncology and Radiotherapy from January 1997 to December 1999. Patients with cTNM stage IV and inoperable stage III were included; those who defaulted or were lost to follow-up were excluded. Out of 473 patients, 372 were selected. The selected patients were divided into groups on the basis of place and type of local treatment they received: (1) local excision only, (2) standard breast conservation therapy (BCT), (3) total mastectomy (TM) + axillary lymph node dissection + radiotherapy (RT), and (4) modified radical mastectomy (MRM) + RT. Data regarding recurrence and survival were analyzed in December 2005. Minimum follow-up was 6 years. RESULTS:Overall recurrence rates were significantly higher in patients operated elsewhere (P <0.0001). Of 194 operated at our Breast Unit, 25 (14.6%) of 171 MRM patients and none of 23 BCT had recurrence. Of 178 patients operated elsewhere, 44 (100%), 6 (42.9%), 41 (41%), and 8 (40%) developed recurrence in groups 1, 2, 3, and 4 respectively. Overall survival was significantly better in patients with MRM at our unit versus TM outside (93.6% vs. 80%). CONCLUSIONS:Several types of treatment from improper local excision alone, BCT, TM, to a carefully done MRM are prevalent here. Properly done, MRM yields significant local control with survival benefit and appears to remain the gold standard in management of our BC patients.

译文

背景:本研究旨在分析该地区流行的乳腺癌(BC)的不同治疗方法,它们对患者生存的影响,并在可用资源范围内讨论最合适的方法。
方法:该研究是在印度北部的一家三级保健医院进行的。我们回顾性回顾了1997年1月至1999年12月就诊于外科肿瘤和放射治疗科的473例女性BC患者的数据。那些违约或失去随访的人被排除在外。在473名患者中,选择了372名。根据所接受的局部治疗的位置和类型将选定的患者分为几类:(1)仅局部切除,(2)标准乳房保留疗法(BCT),(3)全乳房切除术(TM)腋窝淋巴结清扫术放射疗法(RT)和(4)改良根治性乳房切除术(MRM)RT。有关复发和生存的数据于2005年12月进行了分析。最低随访时间为6年。
结果:在其他地方手术的患者的总体复发率显着更高(P <0.0001)。在我们的乳房科进行的194例手术中,171例MRM患者中有25例(占14.6%),而23例BCT均未复发。在178例在其他地方手术的患者中,分别在第1、2、3和4组中复发了44例(100%),6例(42.9%),41例(41%)和8例(40%)复发。我们单位的MRM患者的总生存期明显优于室外TM(93.6%vs. 80%)。
结论:从单独的不当局部切除,BCT,TM到精心制作的MRM的几种治疗方法在这里很普遍。正确完成后,MRM可以产生明显的局部控制并具有生存获益,并且似乎仍然是我们BC患者治疗的金标准。

+1
+2
100研值 100研值 ¥99课程
检索文献一次
下载文献一次

去下载>

成功解锁2个技能,为你点赞

《SCI写作十大必备语法》
解决你的SCI语法难题!

技能熟练度+1

视频课《玩转文献检索》
让你成为检索达人!

恭喜完成新手挑战

手机微信扫一扫,添加好友领取

免费领《Endnote文献管理工具+教程》

微信扫码, 免费领取

手机登录

获取验证码
登录