Intra-nucleus accumbens (Acb) infusion of cholinergic muscarinic antagonist, scopolamine (10 microg/0.5 microl), markedly reduced fat intake elicited by intra-Acb treatment of the mu-opioid receptor agonist, DAMGO, with 30 min and 4h pretreatment intervals. Intra-Acb scopolamine infusions also reduced food intake in food-deprived rats, but not water intake in water-deprived rats. Hence, Acb muscarinic manipulations exhibit some specificity for feeding, perhaps via interactions with the striatal opioid system.

译文

:伏隔核内(Acb)输注胆碱能毒蕈碱拮抗剂东碱(10 microg / 0.5 microl),通过Acb内治疗类阿片受体激动剂DAMGO引起的脂肪摄入显着减少,治疗间隔为30分钟和4小时。 Acb内东in碱的输注也减少了食物匮乏大鼠的食物摄入,但没有减少水缺乏大鼠的水摄入。因此,Acb毒蕈碱操作可能通过与纹状体阿片样物质系统的相互作用而表现出某些喂养特异性。

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