Decline in MM and MS with aging, defined as sarcopenia, is related with physical disability, poor quality of life and death. Its mechanisms are not fully understood. Testosterone increases muscle protein synthesis. However, the effects of in utero androgen exposure to MM and MS in older adults have not been studied. In utero androgen exposure is inversely related with 2D:4D ratio. The aim of this study was to investigate the relationship between 2D:4D ratio as an indicator of in utero androgen exposure and MM and MS in elderly patients. A total of 151 older adults were included. Calf-circumference (CC) and skeletal muscle mass index (SMI) were used for the assessment of MM and hand grip strength for the assessment of MS. Mean age ± SD of the patients was 73.72 ± 6.23. Fifty-two (34.4%) of patients were male, 99 (65.6%) were female. Right and left 2D:4D were significantly and negatively correlated with hand grip strength (r=-0.365, p=0.018 and r=-0.434, p=0.005, respectively), CC (r=-0.422, p=0.002 and r=-0.459, p=0.001, respectively) and SMI (r=-0.354, p=0.018 and r=-0.348, p=0.022, respectively) in men. In women, right and left 2D:4D were significantly and negatively correlated with hand grip strength (r=-0.252, p=0.022 and r=-0.234, p=0.033, respectively), CC (r=-0.229, p=0.024 and r=-0.302, p=0.003, respectively) and SMI (r=-0.382, p<0.001 and r=-0.431, p<0.001, respectively). In this study, we found that 2D:4D ratio was significantly and negatively correlated with parameters depicting MM and MS which may suggest the possible role of in utero androgen exposure in the development of MM and MS loss in the elderly.

译文

:衰老的MM和MS的下降(定义为肌肉减少症)与身体残疾,不良的生活和死亡质量有关。其机制尚不完全清楚。睾丸激素可增加肌肉蛋白质的合成。但是,尚未研究子宫内雄激素暴露于老年人的MM和MS的影响。在子宫内,雄激素暴露与2D:4D比率成反比。这项研究的目的是调查老年患者子宫内雄激素暴露的指标2D:4D比值与MM和MS之间的关系。总共包括151位老年人。小腿围(CC)和骨骼肌质量指数(SMI)用于MM评估,手握力用于MS评估。患者的平均年龄±SD为73.72±6.23。男性(52)(34.4%),女性(99)(65.6%)。左右2D:4D与握力强度显着负相关(分别为r = -0.365,p = 0.018和r = -0.434,p = 0.005),CC(r = -0.422,p = 0.002和r = -0.459,p = 0.001)和SMI(r = -0.354,p = 0.018和r = -0.348,p = 0.022)。在女性中,左右2D:4D与握力强度显着负相关(分别为r = -0.252,p = 0.022和r = -0.234,p = 0.033),CC(r = -0.229,p = 0.024)和r = -0.302,p = 0.003)和SMI(r = -0.382,p <0.001和r = -0.431,p <0.001)。在这项研究中,我们发现2D:4D比率与描述MM和MS的参数显着负相关,这可能表明子宫内雄激素暴露在老年人MM和MS丢失发展中的可能作用。

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