In this review, we aim at establishing a relationship between the fundamentals of the microfluidics technologies used in the Pharmacy field, and the achievements accomplished by those technologies. We describe the main methods for manufacturing micrometer drops, bubbles, and capsules, as well as the corresponding underlying physical mechanisms. In this regard, the review is intended to show non-specialist readers the dynamical processes which determine the success of microfluidics techniques. Flow focusing (FF) is a droplet-based method widely used to produce different types of fluid entities on a continuous basis by applying an extensional co-flow. We take this technique as an example to illustrate how microfluidics technologies for drug delivery are progressing from a deep understanding of the physics of fluids involved. Specifically, we describe the limitations of FF, and review novel methods which enhance its stability and robustness. In the last part of this paper, we review some of the accomplishments of microfluidics when it comes to drug manufacturing and delivery. Special attention is paid to the production of the microencapsulated form because this fluidic structure gathers the main functionalities sought for in Pharmacy. We also show how FF has been adapted to satisfy an ample variety of pharmaceutical requirements to date.

译文

在这篇评论中,我们旨在建立药学领域中使用的微流体技术的基础与这些技术所取得的成就之间的关系。我们描述了制造千分尺液滴,气泡和胶囊的主要方法,以及相应的潜在物理机制。在这方面,该评论旨在向非专业读者展示决定微流体技术成功的动力学过程。流动聚焦 (FF) 是一种基于液滴的方法,广泛用于通过应用扩展共流在连续基础上产生不同类型的流体实体。我们以这项技术为例,说明用于药物输送的微流体技术如何从对所涉及流体的物理原理的深刻理解中发展。具体来说,我们描述了FF的局限性,并回顾了增强其稳定性和鲁棒性的新颖方法。在本文的最后一部分中,我们回顾了微流体在药物制造和输送方面的一些成就。特别注意微囊形式的生产,因为这种流体结构收集了药学中寻求的主要功能。我们还展示了FF是如何适应到目前为止满足大量药物需求的。

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