OBJECTIVE:The dihydrotestosterone:testosterone ratio seems to be an important factor in the expression of androgenic activity, especially in the prostate and pilosebaceous unit. Whereas the decline of testosterone (T) in aging men is well known, controversial data can be found in literature concerning the age dependence of dihydrotestosterone (DHT) levels. Data from the database of the Institute of Endocrinology served as the basis for the definition of the life span curve for the ratio dihydrotestosterone : testosterone. METHODS:The results of testosterone and dihydrotestosterone obtained immunoassays from 10 251 male patients were used in the construction of the curve. RESULTS:The data show that after a peak of DHT:T in infancy and a subsequent decrease in puberty, the ratio of both androgens remains practically without change from approx. 20 years of age till old age. CONCLUSION:High DHT:T ratio in infancy decreases at puberty and throughout the entire reproductive period of life this ration remains practically constant.

译文

目的:二氢睾丸激素:睾丸激素的比例似乎是雄激素活性表达的重要因素,尤其是在前列腺和毛囊皮脂腺中。尽管衰老男性的睾丸激素(T)下降是众所周知的,但是在有关双氢睾丸激素(DHT)水平的年龄依赖性的文献中可以找到有争议的数据。内分泌研究所数据库的数据作为定义二氢睾丸激素:睾丸激素比率的寿命曲线的基础。
方法:采用10 251例男性患者的睾丸激素和二氢睾丸激素的免疫分析结果绘制曲线。
结果:数据显示,在婴儿期DHT:T达到峰值并随后青春期减少之后,两种雄激素的比例实际上保持不变。直到20岁为止。
结论:婴儿期高DHT:T比率在青春期下降,并且在整个生命周期中,这种比率实际上保持恒定。

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